SETTING AND TRACKING YOUR PAH PATIENT GOALS

The 2015 ESC/ERS Guidelines recommend follow-up assessments every 3 to 6 months for stable patients with PAH.2  Since PAH can progress rapidly, it is critical to monitor your patients often.3

ERS=European Respiratory Society; ESC=European Society of Cardiology; PAH=pulmonary arterial hypertension; WHO=World Health Organization

ASSESS AND MONITOR PATIENT RISK STATUS2*
Select a risk level:
Low Risk
Intermediate Risk
High Risk
Low Risk
Low Risk
Intermediate Risk
Intermediate Risk
High Risk
High Risk

The guidelines above can assist with:

  • Creating goals and monitoring progress to help guide the course of treatment
  • Setting goals for your PAH patients that include exercise capacity (6MWD), WHO functional class, and hemodynamics

6MWD=6-minute walk distance;

BNP=brain natriuretic peptide;

CI=cardiac index;

CMR=cardiac magnetic resonance;

NT-proBNP=N-terminal pro-brain natriuretic peptide;

pred.=predicted;

RA=right atrium;

RAP=right atrial pressure;

SvO2=mixed venous oxygen saturation;

VE/VCO2=ventilatory equivalents for carbon dioxide;

VO2=oxygen consumption

6MWD=6-minute walk distance;

BNP=brain natriuretic peptide;

CI=cardiac index;

CMR=cardiac magnetic resonance;

NT-proBNP=N-terminal pro-brain natriuretic peptide;

pred.=predicted;

RA=right atrium;

RAP=right atrial pressure;

SvO2=mixed venous oxygen saturation;

VE/VCO2=ventilatory equivalents for carbon dioxide;

VO2=oxygen consumption

PAH facts
PAH facts
Dictionary
CLINICAL DEFINITION

PAH is defined as a mean pulmonary artery pressure (mPAP) >25 mm Hg with a pulmonary capillary wedge pressure (PCWP) ≤15 mm Hg measured by cardiac catheterization.3

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TREATMENT LANDSCAPE

The REVEAL Registry evaluated 2525 patients, of whom 2438 were on PAH treatment with ERAs, PCAs, or PDE-5 inhibitors. More than 50% of these patients remained in WHO functional class III or IV.4

Evaluation for etiologies other than PAH is appropriate in all instances.
To rule out CTEPH (WHO Group 4), a V/Q scan should be performed.3,5

CTEPH=chronic thromboembolic pulmonary hypertension; ERA=endothelin receptor antagonist; PCA=prostacyclin analog; PDE-5=phosphodiesterase type 5; V/Q=ventilation/perfusion

WHO Group identification
WHO Group identification

WHO GROUP CLASSIFICATION1,6

Identify which WHO group your PH patients are in.

I.PAH

II.PH due to left heart disease

III.PH due to lung disease and/or hypoxia

IV.CTEPH

V.PH with unclear multifactorial mechanisms

 

Adempas is approved for adults with PAH (WHO Group 1) and inoperable or persistent/recurrent CTEPH (WHO Group 4) after surgery. Adempas has been studied predominantly in WHO functional class II-III patients.1

PH=pulmonary hypertension

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Learn about efficacy and safety.

Find out how Adempas can help here.

MORE IMPORTANT SAFETY INFORMATION LESS IMPORTANT SAFETY INFORMATION
References:
  1. Adempas Prescribing Information. Whippany, NJ. Bayer Pharmaceuticals Inc., 2018.
  2. Galiè N, Humbert M, Vachiery JL, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2016;37(1):67-119.
  3. McLaughlin VV, Archer SL, Badesch BD, et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: developed in collaboration with the American College of Chest Physicians, American Thoracic Society Inc., and the Pulmonary Hypertension Association. Circulation. 2009;119(16):2250-2294.
  4. Badesch DB, Raskob GE, Elliot CG, et al. Pulmonary arterial hypertension: baseline characteristics from the REVEAL Registry. Chest. 2010;137(2):376-387.
  5. Hoeper MM, Barberà JA, Channick RN, et al. Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension. J Am Coll Cardiol. 2009;54(1 Suppl):S85-96.
  6. Simonneau G, Gatzoulis MA, Adatia I, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2013;62(25 Suppl):D34-D41.

PAH Facts