PERSONALIZED DOSING FOR YOUR PATIENTS

dosing pill
RECOMMENDED STARTING DOSE1

Start with 1 mg taken 3x a day

For patients who may not tolerate the hypotensive effects of Adempas,
consider a starting dose of 0.5 mg taken 3x a day.

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TITRATION THROUGH MAINTENANCE

Individualized dose adjustments

If systolic blood pressure remains >95 mm Hg and the patient has no signs or symptoms of hypotension, up-titrate the dose by 0.5 mg. Dose increases should be no sooner than 2 weeks apart. The dose can be increased to the highest tolerated dosage, up to a maximum of 2.5 mg taken 3x a day.1

If at any time the patient has symptoms of hypotension, decrease the dosage by 0.5 mg.1

AN ALTERNATIVE FOR PATIENTS
WHO ARE UNABLE TO SWALLOW WHOLE TABLETS

Adempas may be crushed and mixed with water or soft foods (such as applesauce) immediately before administration.1

Mixed water
Crushed and mixed with water
Apple sauce
Crushed and mixed with soft foods (such as applesauce)

TRANSITION FROM OR TO ADEMPAS

transition timing
TRANSITIONING TO ADEMPAS FROM SILDENAFIL OR TADALAFIL?

Before administering Adempas1:

  • Discontinue sildenafil for at least 24 hours
  • Discontinue tadalafil for at least 48 hours
    • Consider initiating Adempas at a starting dose of 0.5 mg in patients at risk of hypotension
    • Monitor for signs and symptoms of hypotension on initiation
Transition timing
TRANSITIONING TO A PDE-5 INHIBITOR FROM ADEMPAS?

Before administering a PDE-5 inhibitor1:

  • Discontinue Adempas for at least 24 hours
    • Monitor for signs and symptoms of hypotension on initiation and on treatment with strong CYP and P-gp/BCRP inhibitors

CYP=cytochrome P450; PDE-5=phosphodiesterase type 5; P-gp/BCRP=P-glycoprotein/breast cancer resistance protein

DOSAGE CONSIDERATIONS1

Dosage interruption

  • If a dose is missed, advise patients to continue with the next regularly scheduled dose
  • In case Adempas is interrupted for 3 days or more, re-titrate Adempas

Pregnancy testing in females of reproductive potential

  • Obtain pregnancy tests prior to initiation and monthly during treatment

Use in patients who smoke

  • Consider titrating to dosages higher than 2.5 mg 3x a day, if tolerated, in patients who smoke
  • A dose decrease may be required in patients who stop smoking

Strong CYP and P-gp/BCRP inhibitors

  • Consider a starting dose of 0.5 mg, 3x a day when initiating Adempas in patients receiving strong CYP and P-gp/BCRP inhibitors such as azole antimycotics (for example, ketoconazole and itraconazole) or HIV protease inhibitors (such as ritonavir)
  • Monitor for signs and symptoms of hypotension on initiation and on treatment with strong CYP and P-gp/BCRP inhibitors
Personalized Patient Support

From initiation through titration, the aim patient support program offers nursing support for your patients every step of the way

PATIENT DIAGNOSIS
Nurse
NURSE INITIATES STARTING DOSE
Assess
ASSESS
NURSE FOLLOW UP VISITS

Nurse visits continue to review titration progress in consultation with the HCP and follow up on the patient’s specific needs

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Want help with patient support?

Learn more about the Aim Patient Support Program here.

MORE IMPORTANT SAFETY INFORMATION LESS IMPORTANT SAFETY INFORMATION
References:
  1. Adempas Prescribing Information. Whippany, NJ. Bayer Pharmaceuticals Inc., 2018.

DOSING + ADMINISTRATION